Santa Maria do Salto is a municipality in the northeast of the Brazilian state of Minas Gerais. Its population in 2007 was 5,724 inhabitants in a total area of 442 km².

Santa Maria do Salto belongs to the Almenara statistical microregion. The elevation of the municipal seat is 220 meters. It became a municipality in 1962. This municipality is located south of the Jequitinhonha River and is bordered by the state of Espírito Santo on the east. Neighboring municipalities are: Eunápolis, Salto da Divisa, and Jacinto. There are poor highway connections with Salto da Divisa, 68 km to the northeast, which has paved connections to the important BR-101, 48 km to the east.