南圣克鲁斯（葡萄牙语：Santa Cruz do Sul）是巴西南大河州的一个市镇。总面积733.473平方公里，总人口115930人，人口密度158.1人/平方公里。

• 南大河州市镇列表

Santa Cruz do Sul ( pronunciation ) is a city in central Rio Grande do Sul, Brazil. The city has approximately 130,000 inhabitants and sits about 150 km (about 93 miles) from the capital city of the state, Porto Alegre. The city enjoys a high standard of living and gross income per capita is 2.5 times greater than that of the state of Rio Grande do Sul as a whole.