Tetanospasmin works by entering special inhibitory neurons called Renshaw cells.
破伤风痉挛毒素通过进入抑制性神经元闰绍细胞而发挥作用。
Osmosis-微生物
In tetanus, Renshaw cells fail to work and the alpha motor neuron keeps firing without any inhibitory control, causing muscle rigidity and spasm.
破伤风患者中,闰绍细胞失去其功能,α运动神经元失去上级抑制,持续兴奋引起肌肉强直收缩和痉挛。
Osmosis-微生物
The role of Renshaw cells and inhibitory neurotransmitters is to fine-tune the action of the alpha motor neuron, which is in charge of sending the actual signal for contraction to the muscle.
闰绍细胞和抑制性神经递质可调整α神经元的运动;α神经元负责向肌肉发送收缩信号。
Osmosis-微生物
All right as a quick recap, Clostridium tetani is a sporulating, gram-positive, bacillus anaerobe that makes the toxin tetanospasmin, which causes tetanus by disrupting the release of inhibitory neurotransmitters from Renshaw cells.
Renshaw cells are inhibitory interneurons found in the gray matter of the spinal cord, and are associated in two ways with an alpha motor neuron.
In this way, Renshaw cell inhibition represents a negative feedback mechanism. A Renshaw cell may be supplied by more than one alpha motor neuron collateral and it may synapse on multiple motor neurons.