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词汇 PNMT
分类 英语词汇 英语翻译词典
释义

PNMT

中文百科

苯乙醇胺N-甲基转移酶 Phenylethanolamine N-methyltransferase

(重定向自PNMT)
苯基乙醇胺N-甲基转移酶在合成肾上腺素的最后步骤中施行转换

苯基乙醇胺N-甲基转移酶英语:Phenylethanolamine N-methyltransferase;PNMT)是一个存在于肾上腺髓质的酶,其将去甲肾上腺素转换为肾上腺素。

此酶受皮质醇的正影响,后者由肾上腺皮质产生出来。

S-腺苷-L-甲硫氨酸(SAM)是一个需要用的辅因子。

英语百科

Phenylethanolamine N-methyltransferase 苯乙醇胺N-甲基转移酶

(重定向自PNMT)
This is a representation of the disulfide bond made between monomers of PNMT. It was made using Chimera and 4MQ4.[1]This is a model of the active site of PNMT showing both the distance between amino and sulfur groups, and a proposed area for methyl transfer. It was made using Chimera and 4MQ4.[1]
Structure illustration


Human biosynthesis pathway for trace amines and catecholamines[8][9]

 
 

L-Phenylalanine
L-Tyrosine
L-Dopa
Epinephrine

Phenethylamine
p-Tyramine
Dopamine
Norepinephrine

N-Methylphenethylamine
N-Methyltyramine
p-Octopamine
Synephrine
3-Methoxytyramine

AADC
AADC
AADC

PNMT
PNMT
PNMT
PNMT

AAAH
AAAH
COMT
DBH
DBH


PNMT plays an important role in trace amine and catecholamine biosynthesis.

Phenylethanolamine N-methyltransferase (PNMT) is an enzyme found in the adrenal medulla that converts norepinephrine (noradrenaline) to epinephrine (adrenaline).

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