Something is radically amiss in our health care system.我们的保健制度存在重大缺陷。On examination, the gun was found to be seriously defective.经过检查发现这种枪存在重大缺陷。The product is guaranteed to be free of/from major defects.这种产品保证无重大缺陷。The system suffers from two major drawbacks.该系统存在两个重大缺陷。