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词汇 Nuclear receptor
分类 英语词汇 英语翻译词典
释义

Nuclear receptor

中文百科

核受体

核受体是细胞内一类转录因子的统称。核受体超家族的成员在细胞生长、发育、分化与新陈代谢均起到了重要的作用。由于核受体都位于细胞内部,因此它们的激素均为溶脂性,这样才能穿越由脂肪构成的细胞膜。对核受体的研究始于20世纪70年代,70年代末期第一批核受体被提取、分离了出来。核受体同激素结合后被激活,激活后的核受体复合物负责引导靶基启动因子的转录。

英语百科

Nuclear receptor 核受体

Crystallographic structure of a heterodimer of the nuclear receptors PPAR-γ (green) and RXR-α (cyan) bound to double stranded DNA (magenta) and two molecules of the NCOA2 coactivator (red). The PPAR-γ antagonist GW9662 and RXR-α agonist retinoic acid are depicted as space-filling models (carbon = white, oxygen = red, nitrogen = blue, chlorine = green).[1]
Structures of selected endogenous nuclear receptor ligands and the name of the receptor that each binds to.
Structural Organization of Nuclear ReceptorsTop – Schematic 1D amino acid sequence of a nuclear receptor.Bottom – 3D structures of the DBD (bound to DNA) and LBD (bound to hormone) regions of the nuclear receptor.   The structures shown are of the estrogen receptor.  Experimental structures of N-terminal domain (A/B), hinge region (D), and C-terminal domain (F) have not been determined therefore are represented by red, purple, and orange dashed lines, respectively.

In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules. In response, these receptors work with other proteins to regulate the expression of specific genes, thereby controlling the development, homeostasis, and metabolism of the organism.

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