《东方快车谋杀案》（Murder on the Orient Express）是著名的英国推理小说作家阿嘉莎·克莉丝蒂的作品之一，主角为名侦探赫丘勒·白罗，英国柯林斯犯罪俱乐部（Collins Crime Club）于1934年1月1日出版，美国达德米德公司（Dodd, Mead, and Company）则于同年稍后于美国发行，书名为加莱车厢谋杀案（Murder in the Calais Coach）。《东方快车谋杀案》被广泛的认为是阿嘉莎·克莉丝蒂生涯最杰出与最著名的作品之一。1974年的同名电影《东方快车谋杀案》被认为是阿嘉莎·克莉丝蒂的作品中最成功的改编电影之一。

Murder on the Orient Express is a detective novel by Agatha Christie featuring the Belgian detective Hercule Poirot. It was first published in the United Kingdom by the Collins Crime Club on 1 January 1934. In the United States, it was published on 28 February 1934, under the title of Murder in the Calais Coach, by Dodd, Mead and Company. The U.K. edition retailed at seven shillings and sixpence (7/6) and the U.S. edition at $2.00.