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词汇 Macromolecular crowding
分类 英语词汇 英语翻译词典
释义

Macromolecular crowding

英语百科

Macromolecular crowding

Macromolecular crowding in the cytosol of cells alters the properties of macromolecules such as proteins and nucleic acids.
The volume of accessible solvent (red) for two molecules of widely different sizes (black circles) at high concentrations of macromolecules (grey circles). Reducing the available volume increases the effective concentration of macromolecules.

The phenomenon of macromolecular crowding alters the properties of molecules in a solution when high concentrations of macromolecules such as proteins are present. Such conditions occur routinely in living cells; for instance, the cytosol of Escherichia coli contains about 300–400 mg/mL of macromolecules. Crowding occurs since these high concentrations of macromolecules reduce the volume of solvent available for other molecules in the solution, which has the result of increasing their effective concentrations.

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