Isopropylmalic acid
![](/Images/godic/202501/21/2-Isopropylmalic_acid.svg1428.png")
![](/Images/godic/202501/21/3-Isopropylmalic_acid.svg1428.png")
Isopropylmalic acid (isopropylmalate) is an intermediate in the biosynthesis of leucine, synthesized from oxoisovalerate by 2-isopropylmalate synthase and converted into isopropyl-3-oxosuccinate by 3-isopropylmalate dehydrogenase. Two isomers are important, the 2- and 3-isopropyl derivatives, and these are interconverted by isopropylmalate dehydratase.