With functional hypothalamic amenorrhea due to anorexia, there's significant weight loss and decreased bone density which can cause fractures.

由于厌食导致的功能性下丘脑性闭经患者往往减重过度且骨密度下降，易致骨折。

Next, there's functional hypothalamic amenorrhea, which is when there is a decrease in GnRH secretion, leading to low levels of LH, FSH, and estrogen.

其次是功能性下丘脑性闭经，即由于GnRH分泌下降导致LH、FSH和雌激素水平下降。

Causes of secondary amenorrhea can also cause primary amenorrhea, and they include functional hypothalamic amenorrhea, polycystic ovary syndrome, hyperprolactinemia, premature ovarian failure and Asherman syndrome.

继发性闭经的病因也可以导致原发性闭经，包括功能性下丘脑性闭经、多囊卵巢综合症、高泌乳素血症、卵巢早衰以及Asherman综合征。