Cells become cancerous after subtle mutations occur that prevent them from carrying out their proper function.由于发生的微妙变化阻止了细胞发挥正常功能，细胞发生了癌变。We can use our eyes and facial expressions to communicate virtually every subtle nuance of emotion there is.我们用眼睛和面部表情几乎就能传达出情感上的每一丝微妙变化。Some of the historical nuances are beyond the grasp of most children.一些历史事件的微妙变化超越了大部分孩子的理解力。