Since this happens within the vasculature, it's called intravascular hemolysis.

由于这种情况发生在脉管系统内，因此称作血管内溶血。

First, they damage the RBC membrane, resulting in intramedullary hemolysis, or RBC breakdown in the bone marrow; or extravascular hemolysis, when RBCs are destroyed by macrophages in the spleen.

首先，它们会破坏红细胞膜，导致髓内溶血（骨髓中红细胞分解）或血管外溶血（红细胞被脾脏的巨噬细胞破坏）。

It becomes treacherous for red blood cells to navigate through, and before long, they slam up against a clot and get destroyed - a process called hemolysis.

这使红细胞在血管中的流动变得困难重重；它们很快就会撞上血栓而受损，这一过程又称“溶血”。

Free hemoglobin in the plasma is bound by a molecule called haptoglobin and gets recycled, which is why a low haptoglobin level is a sign of intravascular hemolysis.

血浆游离血红蛋白与结合珠蛋白结合，并被循环利用，这也是为何低结合珠蛋白水平是血管内溶血的标志之一。

With extravascular hemolysis, we have macrophages eating up red blood cells more than normal and unconjugated bilirubin production is ramped up, which is conjugated by the liver and sent to the gallbladder.

血管外溶血时，巨噬细胞吞噬红细胞，较正常时更多，进而加速了非结合胆红素的产生，非结合胆红素在肝脏转变为结合胆红素，并输送至胆囊。