苏木精-伊红染色，又称苏木素-伊红染色，或“H&E染色”（hematoxylin and eosin stain、H&E stain），是组织学最常用的染色方法之一。

这种染色方法的基础是组织结构对不同染料的结合程度不同。染料苏木精可以将嗜碱性结构染成蓝紫色，而伊红可以将嗜酸性结构染成粉红色。嗜碱性结构通常包括含有核酸的部分，如核糖体、细胞核及细胞质中富含核糖核酸（RNA）的区域等。嗜酸性结构则通常由细胞内及细胞间的蛋白质，如路易体（Lewy body）、酒精小体（Mallory body）、细胞质的大部分等。

Hematoxylin and eosin stain or haematoxylin and eosin stain (H&E stain or HE stain) is one of the principal stains in histology. It is the most widely used stain in medical diagnosis and is often the gold standard; for example when a pathologist looks at a biopsy of a suspected cancer, the histological section is likely to be stained with H&E and termed "H&E section", "H+E section", or "HE section". A combination of hematoxylin and eosin, it produces blues, violets, and reds.