Ogataea polymorpha
![Fig. 1. (A) Micrograph of a budding O. polymorpha cell, grown in a chemostat under methanol conditions. The cytosol is crowded by peroxisomes (after Gellissen et al. 2005).](/Images/godic/202501/17/Kg32309.jpg")
![(B) Methanol metabolism pathway in O. polymorpha (modified after Gellissen et al. 2005). 1 - alcohol oxidase, 2 – catalase, 3 – dihydroxyacetone synthase, 4 – formaldehyde dehydrogenase, 5 – formate dehydrogenase, 6 – dihydroxyacetone kinase, 7 – GSH – glutathione, Xu5P – xylulose-5-phosphate, FBP – fructose-1,6-bisphosphate.](/Images/godic/202501/17/Methanol_metabolism_pathway_in_Ogataea_polymorpha2309.jpg")
![Fig. 2. Design and functionality of CoMed vector system. The CoMed basic vector contains all E. coli elements for propagation in the E. coli system and a MCS for integration of ARS, rDNA, selection marker and expression cassette modules. For this purpose, ARS fragments are flanked by SacII and BcuI restriction sites, rDNA regions by BcuI and Eco47III restriction sites, selection markers by Eco47III and SalI restriction sites and promoter elements by SalI and ApaI restriction sites.](/Images/godic/202501/17/KG1-e-CoMed_vector_system2309.jpg")
Ogataea polymorpha is a methylotrophic yeast with unusual characteristics. It is used as a protein factory for pharmaceuticals.
Ogataea polymorpha belongs to a limited number of methylotrophic yeast species – yeasts that can grow on methanol. The range of methylotrophic yeasts includes Candida boidinii, Pichia methanolica, Pichia pastoris and Ogataea polymorpha. O. polymorpha is taxonomically a species of the Saccharomycetaceae family.