全基因组关联分析 Genome-wide association study

（重定向自GWAS）

An illustration of a Manhattan plot depicting several strongly associated risk loci. Each dot represents a SNP, with the X-axis showing genomic location and Y-axis showing association level. This example is taken from a GWA study investigating microcirculation, so the tops indicates genetic variants that more often are found in individuals with constrictions in small blood vessels.[1]

GWA studies typically identify common variants with small effect sizes (lower right).[7]

Example calculation illustrating the methodology of a case-control GWA study. The allele count of each measured SNP is evaluated—in this case with a chi-squared test—to identify variants associated with the trait in question. The numbers in this example are taken from a 2007 study of coronary artery disease (CAD) that showed that the individuals with the G-allele of SNP1 (rs1333049) were overrepresented amongst CAD-patients.[15]

Regional association plot, showing individual SNPs in the LDL receptor region and their association to LDL-cholesterol levels. This type of plot is similar to the Manhattan plot in the lead section, but for a more limited section of the genome. The haploblock structure is visualized with colour scale and the association level is given by the left Y-axis. The dot representing the rs73015013 SNP (in the top-middle) has a high Y-axis location because this SNP explains some of the variation in LDL-cholesterol.[27]

全基因组关联分析（Genome-wide association study）是指在人类全基因组范围内找出存在的串行变异，即单核苷酸多态性（SNP），从中筛选出与疾病相关的SNPs。

词汇	Gwas
分类	英语词汇英语翻译词典
释义	Gwas 中文百科全基因组关联分析 Genome-wide association study （重定向自GWAS）全基因组关联分析（Genome-wide association study）是指在人类全基因组范围内找出存在的串行变异，即单核苷酸多态性（SNP），从中筛选出与疾病相关的SNPs。英语百科 Gwas GWAS may refer to:
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Gwas

全基因组关联分析 Genome-wide association study

Gwas