So both an MYCN amplification or ALK gene fusion, where the oncogene is " turned on, " or a PHOX2B and chromosome 1 and 11 deletions, where tumor suppressor genes are " turned off, " can potentially cause uncontrolled cell growth.

因此，MYCN基因扩增或ALK基因的融合，即致癌基因被激活，或PHOX2B与1号、11号染色体缺失，即抑癌基因的失活，都可能导致细胞生长不受控制。