Foam cell

Foam cells are fat-laden macrophages seen in atherosclerosis. They are an indication of plaque build-up, or atherosclerosis, which is commonly associated with increased risk of heart attack and stroke.

Foam cells are formed when the body sends macrophages to the location of a fatty deposit on the blood vessel walls. The macrophage surrounds the fatty material in an attempt to destroy it. The cell becomes filled with lipids (fats). The lipids surrounded by the macrophage give it a “foamy” appearance.