Epidemic dropsy

Epidemic dropsy is a form of edema of extremities due to intoxication with Argemone mexicana (Mexican prickly poppy).

Epidemic dropsy is a clinical state resulting from use of edible oils adulterated with Argemone mexicana seed oil.

Sanguinarine and dihydrosanguinarine are two major toxic alkaloids of argemone oil, which cause widespread capillary dilatation, proliferation and increased capillary permeability. When mustard oil is adulterated deliberately (as in most cases) or accidentally with argemone oil, proteinuria (specifically loss of albumin) occurs, with a resultant edema as would occur in nephrotic syndrome.