卡萨芒斯河（法语：Casamance Fleuve）是塞内加尔的河流，向西流进大西洋，河道全长320公里，其中只有130公里可让船只航行，是科尔达区和济金绍尔区的主要河流。

The Casamance River flows westward for the most part into the Atlantic Ocean along a path about 200 miles (320 km) in length. However, only 80 miles (130 km) of it are navigable. The Casamance is the principal river of the Kolda, Sédhiou, and Ziguinchor Regions in the northern portion of Senegal between the Gambia and Guinea-Bissau. The three regions are also collectively known as Casamance after the river.