Campoli Appennino is a comune (municipality) in the Province of Frosinone in the Italian region Lazio, located about 100 kilometres (62 mi) east of Rome and about 30 kilometres (19 mi) northeast of Frosinone.

Campoli Appennino borders the following municipalities: Alvito, Broccostella, Pescasseroli, Pescosolido, Posta Fibreno, Sora, Villavallelonga. It is home to a medieval tower, 25 metres (82 ft) high, a series of walls, and the "Aqueduct of Nero".