郅支单于（？-前36年）全称郅支骨都侯单于，名呼屠吾斯，是匈奴的单于，于前56年—前36年在位，第12代虚闾权渠单于之子，呼韩邪单于的哥哥。

前60年，匈奴因握衍朐提单于不得人心，造成五单于争位的内乱，郅支当时本为左贤王，进位为单于，他打败杀死了握衍朐提单于，又打败了占有蒙古东部的呼韩邪加以流放，使之投降汉朝。其他向西域发展，攻打乌孙，迫使康居求和，并在当地筑城。前36年汉朝西域都护甘延寿和副校尉陈汤派兵攻打，城陷，郅支单于死。

Zhizhi Chanyu (郅支單于, died 36 BC) was a Chanyu of the Xiongnu at the time of the first Xiongnu civil war, who held the north and west in contention with his younger brother Huhanye who held the south. His original name in Chinese transcription was Luanti Hutuwusi (攣鞮呼屠吾斯), i.e. one of the Worthy Princes of the East (of the Luandi clan).