And alpha thalassemia is caused by mutations in the alpha genes, most commonly a gene deletion.
而α地中海贫血是由α基因变异引起的,最常见的原因是基因缺失。
Osmosis-遗传
With moderate alpha thalassemia, there may be golf-ball like RBCs, due to precipitated HbH molecules.
中度α地中海贫血患者,由于HbH分子沉积,可见高尔夫球样红细胞。
Osmosis-遗传
If a person has two defective alpha genes, the person has alpha thalassemia minor, which causes mild symptoms.
如果有2个α基因异常,则会出现轻度α地中海贫血,会引起轻微的症状。
Osmosis-遗传
The initial symptoms of minor and moderate alpha thalassemia are due to anemia, which include pallor, shortness of breath, and easy fatigability.
轻度和中度α地中海贫血的首发症状往往是贫血,表现为苍白、气促、乏力。
Osmosis-遗传
All right, as a quick recap: alpha thalassemia is an autosomal recessive disorder caused by deletion of alpha globin genes on chromosome 16.
得!快速回顾一下:α地中海贫血是一种常染色体隐性遗传病,由16号染色体上的α珠蛋白基因缺陷引起。
英语百科
Alpha-thalassemia
(重定向自Alpha Thalassemia)
Alpha-thalassemia (α-thalassemia, α-thalassaemia) is a form of thalassemia involving the genes HBA1 and HBA2. Alpha-thalassemia is due to impaired production of alpha chains from 1,2,3, or all 4 of the alpha globin genes, leading to a relative excess of beta globin chains. The degree of impairment is based on which clinical phenotype is present (how many genes are affected).