Due to the severity of these complications with larger defects, surgical closure of the VSD might be needed.

更大的缺损会导致这些并发症更严重，就需要行手术关闭室间隔缺损。

Large atrial septal defects that cause clinically significant symptoms usually require surgical closure.

大型房间隔缺损会导致有临床意义的症状，通常需要手术封闭。