Sanfilippo syndrome
（重定向自San filippo syndrome）
![Sanfilippo syndrome has an autosomal recessive pattern of inheritance.](/Images/godic/202502/09/Autorecessive.svg2008.png")
Sanfilippo syndrome, or mucopolysaccharidosis III (MPS-III) is a rare autosomal recessive lysosomal storage disease. It is caused by a deficiency in one of the enzymes needed to break down the glycosaminoglycan heparan sulfate (which is found in the extra-cellular matrix and on cell surface glycoproteins).