Picornain 3C

Picornain 3C (EC3.4.22.28, Picornain 3C is a protease and endopeptidase enzyme found in the picornavirus, that cleaves peptide bonds of non- terminal sequences. Picornain 3C’s proteinase activity is primarily responsible for the catalytic process of selectively cleaving Gln-Gly bonds in the polyprotein of poliovirus and substitution of Glu for Gln, and Ser or Thr for Gly in other picornaviruses. Picornain 3C are cysteine proteases related by amino acid sequence to trypsin-like serine proteases. Picornain 3C is encoded by enteroviruses, rhinoviruses, aphtoviruses and cardioviruses. These genera all cause a wide range of infections for humans and other mammals.