Proprotein convertase 1
（重定向自Prohormone convertase 1）
![](/Images/godic/202502/04/PDB_1kn6_EBI4622.jpg")
Proprotein convertase 1, also known as prohormone convertase, prohormone convertase 3, or neuroendocrine convertase 1 and often abbreviated as PC1/3 is an enzyme that in humans is encoded by the PCSK1 gene. PCSK1 and PCSK2 differentially cleave proopiomelanocortin and they act together to process proinsulin and proglucagon in pancreatic islets.