米斯科是危地马拉的城市，由危地马拉省，位于该国中南部，距离首都危地马拉市19公里，始建于1526年，面积132平方公里，海拔高度1,600米，2010年人口688,124。

Mixco is a municipality in the Guatemala department of Guatemala.

Located next to the main Guatemala City municipality, over time it has become part of the Guatemala City Metropolitan Area. Most of Mixco is separated from the city by canyons, for which a multitude of bridges have been created. Ciudad San Cristóbal, one of Guatemala's largest cities, is located in this municipality. It is the third largest city in Guatemala Department, after Guatemala City and Villa Nueva, with a population of 688,124.