密西西比河三角洲（Mississippi River Delta）是一个在全新世形成的、通过密西西比河在注入墨西哥湾时沉积造成的三角洲。在过去5000年中这个沉积过程使得南路易斯安那州的海岸线向墨西哥湾内推进了24至80千米。

密西西比河三角洲是一个重要的生态地区，它包括1.2万平方公里海岸湿地，美国40%的盐沼位于密西西比河三角洲。

密西西比河三角洲也是一个重要的经济区，包括重要港口新奥尔良。美国16%至18%的石油来自这个地区，此外16%的渔业（包括虾、螃蟹和龙虾）也位于这里。

The Mississippi River Delta region is a 3-million-acre (12,000 km) area of land that stretches from Vermillion Bay on the west, to the Chandeleur Islands in the Gulf of Mexico on the southeastern coast of Louisiana. It is part of the Louisiana coastal plain, one of the largest areas of coastal wetlands in the United States. The Mississippi River Delta is the 7th largest river delta on Earth (USGS) and is an important coastal region for the United States, containing more than 2.7 million acres of coastal wetlands (4,000 square miles (10,000 km) and 37% of the estuarine marsh in the conterminous U.S. The coastal area is the nation’s largest drainage basin and drains about 41% of the contiguous United States into the Gulf of Mexico at an average rate of 470,000 cubic feet per second.