Mestre (Italian pronunciation: [ˈmɛstre]) is the center and the most populated urban area of the mainland of Venice, part of the territory of the Metropolitan City of Venice, in Veneto, northern Italy.

Administratively speaking, Mestre forms (together with the nearby urban area of Carpenedo) the Municipalità di Mestre-Carpenedo, one of the six boroughs of the commune (Comune) of Venice. Sometimes considered as frazione, it is the most populated one of Italy, counting 89,373 inhabitants.