Mechanome

The mechanome consists of the body, or ome, of data including cell and molecular processes relating to force and mechanical systems at molecular, cellular and tissue length scales, i.e. the fundamental "machine code" structures of the cell. The mechanome encompasses biological motors, like kinesin, myosin, RNAP, and Ribosome mechanical structures, like actin or the cytoskeleton, or processes, such as cytokinesis or chemotaxis. The mechanome seeks to understand the fundamental physical-mechanical processes and events that are common to biological function. An example at the molecular level includes the common structural designs used by kinesin and myosin motor proteins (such as dimer formation and mechanochemical cycles) that control their function and lead to properties such as processivity. The mechanome assembles the common features of these motors regardless of the "track" (microtubules, actin filaments, nucleotide based structures, membranes) they move on. A cytoskeletal example includes structures such as actin filament networks and bundles that can form from a variety of actin binding proteins that cross-link or bundle actin filaments leading to common mechanical changes of these structures. A cell machinery example includes common structures such as contractile ring formation formed by both actin and tubulin type structures leading to the same mechanical result of cell division.