南马托格罗索州（葡萄牙语：Mato Grosso do Sul）是巴西西部的一个州，首府大坎普，人口2,297,981 人。该州与玻利维亚和巴拉圭接壤

Mato Grosso do Sul (Portuguese pronunciation: [ˈmatu ˈɡɾosu du ˈsuw]) is one of the Central-Western states of Brazil. Its total area of 357,125 square kilometers, or 137,891 square miles, is roughly the same size of Germany.

Neighboring Brazilian states are (from north clockwise) Mato Grosso, Goiás, Minas Gerais, São Paulo and Paraná. It also borders the countries of Paraguay, to the southwest, and Bolivia, to the west. The economy of the state is largely based on agriculture and cattle-raising. Crossed in the south by the Tropic of Capricorn, Mato Grosso do Sul generally has a warm, sometimes hot, and humid climate, and is crossed by numerous tributaries of the Paraná River.