Changes in chromosome structure are called chromosomal mutations or aberrations.染色体结构的改变称为染色体突变或畸变。The disease eventually deforms the bones.这种病最终会导致骨骼畸变。It's just a tiny little electric circuit, but it can distort the signal.这只是一个很小的电路,却能引起信号畸变。The disease eventually causes the bones to deform.这种病最终会引发骨骼畸变。