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词汇 Inhibition constant
分类 英语词汇 英语翻译词典
释义

Inhibition constant

中文百科

酶抑制剂 Enzyme inhibitor

(重定向自Inhibition constant)
不同的抑制类型。分类参考自[1]。图中,“E”表示酶;“I”表示抑制剂;“S”表示底物;“P”表示产物。
不同的抑制类型。分类参考自[2]。图中,“E”表示酶;“I”表示抑制剂;“S”表示底物;“P”表示产物。
Modelo estructural de la proteasa del virus del sida unida a un inhibidor de la proteasa, el ritonavir. La estructura de la proteasa se muestra mediante cintas de color rojo, azul y amarillo, mientras que el inhibidor es representado por una estructura de esferas y varillas cerca del centro de la proteasa. Modelo creado a partir del PDB 1HXW.
Inhibición competitiva: el sustrato (S) y el inhibidor (I) compiten por el sitio activo (cavidad de la enzima).

zh-hans:不同的抑制类型。分类参考自。图中,“E”表示酶;“I”表示抑制剂;“S”表示底物;“P”表示产物。

酶抑制剂是一类可以结合酶并降低其活性的分子。由于抑制特定酶的活性可以杀死病原体或校正新陈代谢的不平衡,许多相关药物就是酶抑制剂。一些酶抑制剂还被用作除草剂或农药。并非所有能和酶结合的分子都是酶抑制剂,酶激活剂也可以与酶结合并提高其活性。大概可分为竞争性抑制剂非竞争性抑制剂

英语百科

Enzyme inhibitor 酶抑制剂

(重定向自Inhibition constant)
An enzyme binding site that would normally bind substrate can alternatively bind a competitive inhibitor, preventing substrate access. Dihydrofolate reductase is inhibited by methotrexate which prevents binding of its substrate, folic acid. Binding site in blue, inhibitor in green, and substrate in black. (PDB: 4QI9​)
Types of inhibition. This classification was introduced by W.W. Cleland.[3]
Kinetic scheme for reversible enzyme inhibitors
Lineweaver–Burk plots of different types of reversible enzyme inhibitors. The arrow shows the effect of increasing concentrations of inhibitor.

An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. They are also used in pesticides. Not all molecules that bind to enzymes are inhibitors; enzyme activators bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

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