In 1956, a Swiss clinician observed a similar effect when running a trial for imipramine, a drug for allergic reactions.

1956 年，一位瑞士临床医生在对丙咪嗪（一种治疗过敏反应的药物）进行试验时观察到类似的效果。

Ipronaizid, imipramine, and other drugs like them were thought to restore that balance by increasing the availability of monoamines in the brain.

异丙肼、丙咪嗪和其他类似药物被认为可以通过增加大脑中单胺的可用性来恢复这种平衡。

Then, it was found that the drugs iproniazid and imipramine could prevent the lethargy and apathy if given before the depressing drug reserpine — iproniazid and imipramine seemed to have an anti-depressant effect.

研究发现，在摄入蛇根碱前服用异内肼和异内嗪这两种药物，可阻止嗜睡和冷漠等抑郁症状的出现，也就是说，异内肼和异内嗪似乎具有抗抑郁作用。