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词汇 Field cancerization
分类 英语词汇 英语翻译词典
释义

Field cancerization

英语例句库

Field cancerization was the base of double primary lung cancer.

区域性癌化是双原发性肺癌发生的病理基础。

原声例句
Osmosis-消化

Many carcinogens come into contact with a wide area within the oral cavity and oropharynx, so the idea is that they cause field cancerization.

许多致癌物可以广泛接触到口腔和口咽内，故有一个猜想就是这些物质引发区域癌化。

英语百科

Field cancerization

Longitudinally opened freshly resected colon segment showing a cancer and four polyps. Plus a schematic diagram indicating a likely field defect (a region of tissue that precedes and predisposes to the development of cancer) in this colon segment. The diagram indicates sub-clones and sub-sub-clones that were precursors to the tumors.
A colon cancer resection, 22 cm long, had 6 tissue samples evaluated for expression of 3 DNA repair proteins, KU86, ERCC1 and PMS2. All 3 proteins are expressed at near 100% in colon tissue from a person without any colonic neoplasia, but adjacent to a colon cancer, in this instance, there is a field of more than 20 cm in which ERCC1 and PMS2 have reduced expression.

Field cancerization (also termed field change, field change cancerization, field carcinogenesis, cancer field effect or premalignant field defect) is a biological process in which large areas of cells at a tissue surface or within an organ are affected by a carcinogenic alteration(s). The process arises from exposure to an injurious environment, often over a lengthy period.
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