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词汇 FC fragment
分类 英语词汇 英语翻译词典
释义

FC fragment

英语百科

Fragment crystallizable region

(重定向自FC fragment)
An antibody digested by papain yields three fragments, two Fab fragments and one Fc fragment
An antibody digested by pepsin yields two fragments: a F(ab')2 fragment and a pFc' fragment

The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. This property allows antibodies to activate the immune system. In IgG, IgA and IgD antibody isotypes, the Fc region is composed of two identical protein fragments, derived from the second and third constant domains of the antibody's two heavy chains; IgM and IgE Fc regions contain three heavy chain constant domains (CH domains 2–4) in each polypeptide chain. The Fc regions of IgGs bear a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. The N-glycans attached to this site are predominantly core-fucosylated diantennary structures of the complex type. In addition, small amounts of these N-glycans also bear bisecting GlcNAc and α-2,6 linked sialic acid residues.

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