Diclofensine

Diclofensine (Ro 8-4650) was developed by Hoffman-La Roche in the 1970s in the search for a new antidepressant. It was found that the (S) isomer was responsible for activity. Is a stimulant drug which acts as a triple monoamine reuptake inhibitor, primarily inhibiting the reuptake of dopamine and norepinephrine, with affinities (Ki) of 16.8nM, 15.7nM, and 51nM for DA, NE, and 5-HT transporters, respectively. It was found to be an effective antidepressant in human trials, with relatively few side effects, but was ultimately dropped from clinical development, possibly due to concerns about its abuse potential.