The Cordillera de Talamanca is a mountain range that lies on the border between Costa Rica and Panama. Much of the range and the area around it is included in the La Amistad International Park, which also is shared between the two countries.

This range contains in the south of Costa Rica stretches from southwest of San José to beyond the border with Panama and contains the highest peaks of Costa Rica and Panama, among them the Cerro Chirripó with 3,820 m, and the more accessible high peak of Cerro de la Muerte. Much of the Caribbean areas of the range are still unexplored.