大头芋螺（学名：Conus pergrandis）为芋螺科芋螺属下的一个种。

Conus pergrandis, common name the grand cone, is a species of sea snail, a marine gastropod mollusk in the family Conidae, the cone snails and their allies.

Like all species within the genus Conus, these snails are predatory and venomous. They are capable of "stinging" humans, therefore live ones should be handled carefully or not at all.