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词汇 Connexin 43
分类 英语词汇 英语翻译词典
释义

Connexin 43

英语百科

GJA1

(重定向自Connexin 43)
Connexin 43 distribution in the rat myocardium (gap junctions between cardiomyocytes)

Gap junction alpha-1 protein (GJA1), also known as connexin 43 (Cx43), is a protein that in humans is encoded by the GJA1 gene on chromosome 6. As a connexin, GJA1 is a component of gap junctions, which allow for gap junction intercellular communication (GJIC) between cells to regulate cell death, proliferation, and differentiation. As a result of its function, GJA1 is implicated in many biological processes, including muscle contraction, embryonic development, inflammation, and spermatogenesis, as well as diseases, including oculodentodigital dysplasia (ODDD), heart malformations, and cancers.

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