科隆纳家族（意大利语：Colonna）或译科隆那、柯隆那，是一个意大利贵族家族，在中古世纪和意大利文艺复兴时期的罗马拥有强大的势力，该家族成员包括教宗马丁五世、至少20位枢机以及多位政治领袖。该家族因与奥尔西尼家族——另一个罗马强大家族的纷争而为人所知，直到1511年由教宗儒略二世发布的一份教宗诏书后他们停止了斗争。1571年两个家族的首领分别迎娶了西斯都五世的两位姪女。科隆纳在意大利语的意思为「柱子」，所以他们将柱子作为家族徽章。

The Colonna family is an Italian noble family. It was powerful in medieval and Renaissance Rome, supplying one Pope and many other Church and political leaders. The family is notable for its bitter feud with the Orsini family over influence in Rome, until it was stopped by Papal Bull in 1511. In 1571, the heads of both families married nieces of Pope Sixtus V. Thereafter, historians recorded that "no peace had been concluded between the princes of Christendom, in which they had not been included by name".