This way of life can lead only to self-destruction and emotional emptiness.这种生活方式的结果只能是自我毁灭和情感空虚。This propensity to self-destruction is the nemesis of irrationality.这种自我毁灭的倾向是非理性的必然结果。His drinking started him on the path/road to self-destruction.酒瘾使他踏上了自我毁灭的道路。He seems bent on self-destruction.他好像决心要毁掉自己。