梭菌蛋白酶（英语：Clostripain，EC3.4.22.8，其它英文名有：clostridiopeptidase B, clostridium histolyticum proteinase B, alpha-clostridipain, clostridiopeptidase, Endoproteinase Arg-C）是一种从梭菌属溶组织梭状芽胞杆菌（Clostridium histolyticum）中分离出的蛋白酶，在精氨酸的羧基端水解肽键，最适反应pH为7.4~7.8。

Clostripain (EC3.4.22.8, clostridiopeptidase B, clostridium histolyticum proteinase B, alpha-clostridipain, clostridiopeptidase, Endoproteinase Arg-C) is a proteinase that cleaves proteins on the carboxyl peptide bond of arginine. It was isolated from Clostridium histolyticum. The isoelectric point of the enzyme is 4.8-4.9 (at 8°C), and optimum pH is 7.4~7.8 (against α-benzoyl-arginine ethyl ester). The composition of the enzyme is indicated to be of two chains of relative molecular mass 45,000 and 12,500.