Adducted thumb syndrome

Adducted thumb syndrome recessive form, also known as Christian syndrome or Craniostenosis arthrogryposis cleft palate, is a rare disease affecting multiple systems which causes malformations of the palate, thumbs, and upper limbs. The name Christian syndrome derives from Joe. C. Christian the first person to describe the condition. Christian-Andrews-Conneally-Muller syndrome is another term, named after the other authors (P. A. Andrews, P. M. Conneally and Jans Muller) of the original publication. It is an autosomal recessive connective tissue disorder characterized by congenital malformations, contractures of the thumb and feet, a typical facial appearance, and normal cognitive development. This is caused by mutation in the CHST14 (CARBOHYDRATE SULFOTRANSFERASE 14) gene