杯状病毒科（Caliciviridae），又称嵌杯病毒科，是巴尔的摩分类法（Baltimore classification）第四纲病毒，它们具有正股不分节RNA，它门不具有套膜且蛋白壳体为正20面体，它们十分的难培养，故没有许多的研究，Caliciviridae的名字是源自于拉丁文「calyx」意思为杯状，常见的病源体为诺瓦克病毒（Norwalk virus），杯状病毒科主要是借由粪口传染，但也可以借由飞沫传染，杯状病毒主要造成肠胃炎及呕吐及腹泻。

Caliciviridae is a family of viruses, members of Class IV of the Baltimore scheme. They are positive-sense, single stranded RNA which is non-segmented. There are currently seven species in this family, divided among 5 genera. Diseases associated with this family include: feline calicivirus: respiratory disease; rabbit hemorrhagic disease virus: often-fatal hemorrhages; norwalk group of viruses: gastroenteritis. Caliciviruses naturally infect vertebrates, and have been found in a number of organisms such as humans, cattle, pigs, cats, chickens, reptiles, dolphins and amphibians. The caliciviruses have a simple construction and are not enveloped. The capsid appears hexagonal/spherical and has icosahedral symmetry (T=1 or T=3) with a diameter of 35–39 nm.