在分子生物学中，摇摆碱基对（英语：Wobble base pair）为一对华森，克立克碱基对例外的双核苷RNA分子。四个主要摆动碱基鸟嘌呤-脲嘧啶(guanine-uracil)，肌苷-脲嘧啶(inosine-uracil)，肌苷-腺嘌呤(inosine-adenine)和肌苷-胞嘧啶(inosine-cytosine)(以上各简称为GU, IU, IA and IC)。就热力学来说，摇摆咸基对的稳定性与华森-克立克碱基对约略相等。摇摆碱基对为RNA二级结构的基础，对于遗传编码转译的正确性至关重要。

A wobble base pair is a pairing between two nucleotides in RNA molecules that does not follow Watson-Crick base pair rules. The four main wobble base pairs are guanine-uracil (G-U), hypoxanthine-uracil (I-U), hypoxanthine-adenine (I-A), and hypoxanthine-cytosine (I-C). In order to maintain consistency of nucleic acid nomenclature, "I" is used for hypoxanthine because hypoxanthine is the nucleobase of inosine; nomenclature otherwise follows the names of nucleobases and their corresponding nucleosides (e.g., "G" for both guanine and guanosine). The thermodynamic stability of a wobble base pair is comparable to that of a Watson-Crick base pair. Wobble base pairs are fundamental in RNA secondary structure and are critical for the proper translation of the genetic code.