威廉斯堡县（英语：Williamsburg County, South Carolina）是美国南卡罗莱纳州东部的一个县。面积2,427平方公里。根据美国2000年人口普查，共有人口37,217人。县治京斯特里 (Kingstree)。

成立于1802年。县名纪念英王乔治二世的儿子、坎伯兰公爵威廉·奥古斯都 (Prince William Augustus, Duke of Cumberland)。

Williamsburg County is a county located in the U.S. state of South Carolina. As of the 2010 census its population was 34,423. The county seat is Kingstree. After a previous incarnation of Williamsburg County, the current county was created in 1804.