美国内务部（United States Department of the Interior，DOI）负责管理联邦政府拥有的土地和保护自然资源，并负责有关印第安人、阿拉斯加原住民和夏威夷原住民领土事务，和美国岛屿地区。这与大多数国家的内政部负责警察或安全事务不同。

通常美国内务部的部长都由来自美西的人士担任。这是由于大部分的国有地在美国西部。目前的部长是来自华盛顿州的萨里·朱厄尔。

The United States Department of the Interior (DOI) is the United States federal executive department of the U.S. government responsible for the management and conservation of most federal land and natural resources, and the administration of programs relating to Native American, Alaska Natives, Native Hawaiians, territorial affairs, and insular areas of the United States. About 75% of federal public land is managed by the department, with most of the remainder managed by the Agriculture department's United States Forest Service.