乌鲁班巴河（西班牙语：Río Urubamba），位于秘鲁的南美洲河流，是部分可航行的亚马逊河上游。

中游的急流把乌鲁班巴河分为上乌鲁班巴河和下乌鲁班巴河。

1932年6月2日，英籍地质学家约翰·华特·古格里前往安第斯山脉探险时在乌鲁班巴河溺毙。

The Urubamba River or Willkamayu (Quechua for "sacred river") is a river in Peru. Upstream it is called by its Aymara name Willkanuta ("house of the sun", hispanicized Vilcanota). Within the La Convención Province the naming changes to Urubamba. A partially navigable headwater of the Amazon River, it rises in the Andes to the southeast of Cuzco. It originates on the slopes of Khunurana in the Puno Region, Melgar Province, near the La Raya pass. It flows north-north-west for 724 kilometers before coalescing with the Tambo River to form the Ucayali River.