五氯化铀是一种无机化合物，化学式为UCl₅，有放射性。

五氯化铀可以通过四氯化铀在520℃的直接氯化得到：

2 UCl₄ + Cl₂ → 2 UCl₅

这个反应可逆。

三氯化硼和UF₅·3SbF₅在40℃反应也可得到五氯化铀：

UF₅·3SbF₅ + 5 BCl₃ → 2 SbCl₅ + 5 BF₃ + UCl₅

Uranium pentachloride is an inorganic chemical compound composed of uranium in the +5 oxidation state and five chlorine atoms. The gaseous form has C_4v symmetry. There are two crystalline forms, each of which has the uranium atom in an octahedral geometry among six chlorine atoms.